Tag Archives: Postpartum

Oral Allopregnanolone Analogue for Postpartum Depression Treatment

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD).  SAGE-547, now called brexanolone, is a neurosteroid, an analogue of allopregnanolone and an allosteric modulator of GABAA receptors.  Since that time, Sage Therapeutics has conducted three randomized controlled trials, enrolling a total of 247 women diagnosed… Read More »

Sage's postpartum depression treatment benefits outweigh risk: FDA panel

(Reuters) – The benefits of Sage Therapeutics Inc’s experimental treatment for postpartum depression outweigh risks, an advisory panel to the U.S. Food and Drug Administration said on Friday. The panel voted 17 to 1 in favor of the injectable treatment, Zulresso, that aims to treat major episodes of depression during pregnancy or within 4 weeks… Read More »

Is Acupuncture Effective for Postpartum Depression?

In a recent meta-analysis, researchers screened electronic databases and analyzed data from randomized controlled trials (RCTs) of acupuncture for the treatment of postpartum depression (PPD). Primary outcomes included improvement in depressive symptoms, as by scores on the Hamilton Rating Scale for Depression (HAMD) or the Edinburgh Postnatal Depression Scale (EPDS).   The authors identified a… Read More »