Tag Archives: Postpartum

Timing of Postpartum Depression Onset May Predict Symptom Pattern

Postpartum depression (PPD) is a common and complicated illness, affecting about 15% of women in the perinatal period. Recent research from the PACT consortium (Postpartum Depression: Action Toward Causes and Treatment) has sought to classify the many potential subtypes of this heterogenous illness and has found emerging differences in time of onset, severity, comorbid anxiety,… Read More »

Does Exercise During Pregnancy Prevent Postpartum Depression?

While there is some data to indicate that exercise may improve well-being and diminish symptoms of depression and anxiety, the results have been mixed.  A recent randomized controlled trial has explored the efficacy of exercise during pregnancy for reducing the risk of postpartum depression. The Physical Activity for Mothers Enrolled in Longitudinal Analysis (PAMELA) Study… Read More »

Oral Allopregnanolone Analogue for Postpartum Depression Treatment

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD).  SAGE-547, now called brexanolone, is a neurosteroid, an analogue of allopregnanolone and an allosteric modulator of GABAA receptors.  Since that time, Sage Therapeutics has conducted three randomized controlled trials, enrolling a total of 247 women diagnosed… Read More »